The Telomere protects the chromosome from damage. Telomeres are currently recognized as the “clocks of aging” within a cell, as well as protection for the body from cancer and other pathologies. This formula helps the body detox, support the production of the powerful antioxidant – glutathione peroxidase – and supports the health of the cells and telomeres.*
The premise of this formulation has two primary directives; to initiate the biochemical activation known as mercaptate, or mercaptans, by increasing the Thiol group compound concentration and to heighten the catalytic response of the four enzyme groups of Glutathione Peroxidase (GSHPx-1, GSHPx-2, GSHPx-GI and PHGPx). The second is to address the influencing of premature telomere fragmentation.
L-Cysteine and L-Mehtionine are both sulfur containing side chain amino acids which support the glutathione peroxidase groups; the enzymes which assume themselves as reduced anion scavengers. With increased levels of non metabolized (toxic) compounds in the mammalian’s system, the body requires the parallel sequencing in the activation of these enzymes. These enzymes are in close redox association with the thioredoxin and glutathione systems. The Glutathione Peroxidase groups are selenium- dependent enzymes and thus require adequate amounts of this transitional metal for correct structural formation.
Mercaptate is the biochemical process which solubilizes hydrophilic compounds, thus liberating the toxic substances from the lipid envelope (droplet) where they are then excreted in a manner which does not increase their Dalton weight(s). Inhibiting vast increases in Dalton weight essentially translates into a rapid excretion pathway through the renal tubules with other non reabsorbed solutes. In this scenario, we clearly understand why chelating therapies may be only partially effective, as Dalton weights (including Kilo Daltons) increase during the chelating process. The toxic substances which are not destined for urinary excretion are then distributed through a reabsorption process into the bile, where excretion is then observed within the alimentary tract.
This denotes why mercaptans are an effective tool for addressing hyperlipidemia and arterial hypertension. Mercatate, or mercaptans, rely on these two amino acids (L-Cysteine and L-Methionine) to donate thiols. During the catalytic cycle of glutathione peroxidase, sulfenic acid groups are formed, which are recognized as key intermediates in several thiol oxidation activities.
Alpha, Delta and Beta Carotenes have exhibited the ability to quench singlet oxygen species, scavenge peroxyl radicals and halt lipid peroxidation. These processes assist the Glutathione groups in their primary role of reducing organic peroxides.
Telomeres are “end caps” on chromosomes which have been currently recognized as genetic “time clocks”. Their structure and the manner in which they maintain a correct degradation sequence has been recognized in gerontology as one of the premier reasons why premature aging occurs. Telomeres have shown to be “vulnerable” to organic peroxides and reduced oxygen anions. By increasing the activation of the Glutathione peroxidase groups, reduction of reduced oxygen species, which affect the telomere linkage in an adverse way, are arrested.
The potential of this biochemical/genetic influence is far reaching, as the related pathologies associated with premature cell replication has been notably recognized, particularly in neurology and oncology.
Clinical studies are now displaying the therapeutic applications of mercaptans regarding cardiovascular diseases, particularly associated with elevated serum Ca+ salt levels and serum homocysteine concentrates. Myelin perforations, broad diffuse cerebral plaque and reduced neuronal growth have also shown promising signs of abatement. More clinicals are warranted, but thus far, the studies already performed (in vivo) are extremely encouraging.
Summary – The formulation involves the following material:
• The use of the two branched side chain amino acids; L-Cysteine and L-Methionine.
• The transitional element selenium (citrate or aspirate).
• The Alpha, Delta and Beta Carotenes.
Natural Integrative Holistic BioChemistry Dietary Supplements
a name=”google-site-verification” content=”aEaGJJvi_YEFarwiTFWBc71tymQ3JoTwLXvce